Dong Wang

This study presents 43 cryo-EM structures of RNAPII elongation complex during the nucleotide addition cycle, revealing structural dynamics and transition intermediates.

The paper evaluates the cost-impact effectiveness of Open Access journals using three metrics to help researchers choose journals based on cost and impact.

This study investigates the polarity of RNA Polymerase II as a roadblock to DNA replication forks, showing that head-on collisions lead to stable binding and R-loop formation, with TFIIS facilitating hybrid removal.

This study uses cryo-EM to reveal a two-step mechanism of RNA polymerase I stalling at abasic DNA lesions, distinct from other lesion types.

This study examines the rapid structural evolution of de novo genes in rice over 1 million years, finding faster changes in disordered regions and structured elements compared to gene duplicates.

The paper evaluates eight R-loop mapping technologies, identifies biases and artifacts, and classifies R-loops into two distinct types based on RPA binding patterns.

This paper introduces SHERRY, a new RNA-seq method that avoids second strand synthesis by using Tn5 transposase to directly fragment and prime RNA/DNA hybrids, improving reproducibility and GC uniformity.

The paper solves a high-resolution structure of a stalled RNA polymerase II elongation complex using streptavidin affinity grids to overcome air-water interface interactions.