Cancer BiologybioRxivPreprint
Aging directs the differential evolution of KRAS-driven lung adenocarcinoma
Felicia Lazure, Stanislav Drápela, Xiaoxian Liu…·Ana P. Gomes
This study uses single-cell RNA-sequencing to show that aging promotes KRAS-driven lung adenocarcinoma evolution toward a stem-like state through age-related changes in the tumor microenvironment.