Corry‐Anke Brandsma

The paper identifies a novel asthma-associated epithelial differentiation trajectory involving KRT14+ basal cells and hillock-like cells that contributes to airway inflammation and remodelling in childhood-onset asthma.

The paper shows that in IPF lungs, COL6 gene expression is higher but protein levels and synthesis around airways and vessels are lower, suggesting disrupted matrix organization and fibroblast persistence.

This study investigates the role of Piezo1/2 channels in airway smooth muscle cells of COPD patients, finding altered expression and function linked to ECM changes.

This study identifies genetic variants associated with extrapulmonary traits in COPD using genome-wide association analysis across two cohorts.

This study shows RANKL promotes alveolar epithelial cell expansion in mice and humans, suggesting RANKL/RANK signaling as a conserved pathway for lung tissue repair.

The paper identifies fibroblast-derived osteoglycin as a key factor promoting epithelial cell repair and presents its active fragment as a potential therapeutic for lung diseases.

The paper compares ECM protein expression in severe-early onset and moderate COPD to controls, identifying ECM signatures linked to disease severity and subtypes.

This study investigates RANKL's role in lung epithelial cell regeneration, finding it promotes type II alveolar epithelial cell regeneration and may contribute to lung tissue repair.

This study identifies seven age-associated ECM proteins with increased expression in human lung tissue and demonstrates age-related differences in specific lung compartments.

This study uses Mendelian randomisation to show that higher serum CC-16 levels protect against COPD risk and progression, with genetic variants linked to CC-16 expression in lung tissue.

This study uses single-cell RNA sequencing to analyze smoking effects on bronchial epithelial cell types, identifying molecular changes and a novel subpopulation linked to premalignant lesions.

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.