Reinoud Gosens

This paper presents an alveolus-on-chip model to study vascular-epithelial interactions and smoke-induced lung injury, showing that cigarette smoke disrupts vascular networks when exposed to alveolar epithelial cells.

This study shows that cGAS-STING activation in alveolar epithelial cells impairs regeneration and differentiation in response to cigarette smoke exposure.

The paper identifies fibroblast-derived osteoglycin as a key factor promoting epithelial cell repair and presents its active fragment as a potential therapeutic for lung diseases.

This study identifies seven age-associated ECM proteins with increased expression in human lung tissue and demonstrates age-related differences in specific lung compartments.

This paper develops an in vitro model of human airway cholinergic neurons from pluripotent stem cells to study neuroplasticity in respiratory diseases.