Alan D. Cherrington

This study shows that morning insulin exposure enhances afternoon hepatic glucose disposal in dogs by increasing glucose-mediated mechanisms, though maximal effects also require elevated afternoon insulin.

This study investigates whether morning hyperglucagonemia affects the priming effects of morning hyperinsulinemia on subsequent hepatic glucose metabolism in dogs.

This paper develops an ultra-stable insulin-glucagon fusion protein that exploits a hepatic glucose switch to reduce hypoglycemic risk in diabetes, showing improved stability and glycemic control in rats.

The paper investigates how morning insulin delivery route affects afternoon hepatic glucose uptake, finding that direct hepatic insulin signaling, not indirect actions, drives the second meal phenomenon.

The study shows that prolonged morning hyperinsulinemia improves hepatic glucose uptake and glycogen storage during an afternoon clamp compared to shorter, higher-rate insulin delivery.

This study examines how glucagon affects hepatic glucose production and gene expression in conscious dogs over time, revealing transient metabolic flux changes and gene regulation patterns.

This study shows that a high-fat and fructose diet in dogs causes insulin resistance and β-cell dysfunction similar to human impaired glucose tolerance and type 2 diabetes.