Qing Tang

This paper identifies and characterizes a diffusible polymorphic toxin system in Staphylococcus aureus that mediates inter-genus antagonism against Listeria monocytogenes through extracellular proteolysis and ABC transporter-mediated susceptibility.

This study identifies a c-di-AMP-controlled glutamine synthesis pathway critical for survival of Staphylococcus aureus TD-SCVs in the thymidine-limited CF lung.

This study shows that cyclic di-AMP inhibits thymineless death in Listeria monocytogenes during infection, revealing a new regulatory mechanism for bacterial survival under thymidine starvation.

This paper uses a RECON-/- mouse model to perform Tn-seq screening of Listeria monocytogenes in vivo, identifying novel genes critical for bacterial survival and revealing the role of the D-allose operon in pathogenesis.

This study shows that thymidine starvation in bacteria increases c-di-AMP, leading to STING activation and inflammation during infection.