Alexey A. Alekseev

This paper introduces ChReef, an improved optogenetic tool with enhanced performance in sensory and cardiac systems, demonstrating its effectiveness in restoring visual and auditory function.

The paper presents cryo-EM structures of FArhodopsin and proteorhodopsin, showing no retinal binding despite conserved lysine and similar fold to retinal-binding rhodopsins, with mutations identified that prevent retinal binding.

The paper characterizes CryoRhodopsins from cold environments, revealing their dual functionality and structural adaptations to low temperatures.

The paper identifies a new subgroup of light-driven sodium pumps with an additional glutamic acid residue that reduces pH sensitivity for sodium transport.

This study uses qPALM to show ChR2 predominantly forms dimers in the cell membrane, with disulfide bonds not essential for dimerization and partial monomerization observed at low concentrations.

The paper shows that viral channelrhodopsins (VCR1s) induce intracellular calcium release upon illumination, enabling light-controlled muscle contraction in tadpoles, suggesting a new optogenetic tool.

This paper introduces optogenetic tools to control lysosome pH, enabling precise regulation of lysosomal function for studying cellular processes and drug design.