Zhihua Zhou

The paper identifies a novel biosynthetic pathway for baccatin III production using engineered microbes, achieving its complete de novo synthesis through enzymatic validation and pathway engineering.

This study identifies the complete biosynthetic pathway of camptothecin, discovers missing enzymes, and validates the pathway through heterologous reconstruction in yeast.

This study identifies the epoxidase enzyme responsible for converting strictosamide to its epoxide form using a chemoproteomic approach in Ophiorrhiza pumila.