Author

Moritz Binder

Mayo ClinicORCID 0000-0001-9014-9658Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jenna A. FernandeziD· 2 shared Mrinal M. PatnaikiD· 2 shared Abhishek Avinash MangaonkariD· 1 shared Akhilesh PandeyiD· 1 shared Alexandre Gaspar‐MaiaiD· 1 shared Amelia MazzoneiD· 1 shared Amik MunankarmyiD· 1 shared Anjana RaoiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Jenna A. FernandezORCID

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2 papers

Recent·Most cited

Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedJan 3, 2025

A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia

Zhen Dong, Hugo Sepúlveda, Leo J. Arteaga-Vazquez…·Anjana Rao

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.

13 citationstop 2%

mousehuman

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GeneticsbioRxivPreprintAug 25, 2022

Single cell multiomic analyses reveal divergent effects of DNMT3A and TET2 mutant clonal hematopoiesis in inflammatory response

Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder…·Mrinal M. Patnaik

This study uses single cell multiomic analyses to show DNMT3A mutations in clonal hematopoiesis worsen inflammatory outcomes in COVID-19 by increasing IL32 expression and chromatin accessibility.

DOI 10.1101/2022.08.25.505316

humanscRNA-seq

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