Fabian Schulte

The paper uses crosslinking mass spectrometry to map protein interactions in Toxoplasma gondii, identifying novel components of essential complexes and revealing structural diversity in mitochondrial machinery.

The paper identifies NDUFA4L2 as a protein that rescues hyperoxia-induced migration defects in retinal endothelial cells by reversing isocitrate dehydrogenase flux blockade in a mouse model of oxygen-induced retinopathy.

The paper shows that an IGF1-derived peptide reduces IGFBP2 in RTT astrocytes, improving synaptogenesis and mitochondrial function in neurons.

The paper identifies a preoptic neurocircuit that modulates metabolic flexibility by shifting fuel use from glucose to fatty acids through insulin resistance in skeletal muscle.

The paper constructs a multi-tissue lysosomal metabolite atlas in mice, revealing age-related accumulation of glycerophosphodiesters and cystine, linked to lysosomal storage disorders, and shows caloric restriction mitigates these changes in some tissues.

This study identifies a DNA binding region in MORC2 that is essential for gene silencing and shows that phosphorylation affects its DNA affinity and nuclear localization.

The paper identifies distinct chaperone machinery for targeting mitochondrial outer membrane -helical proteins based on their topology using CRISPRi screens and biochemical analysis.