Wim Trypsteen

This study links HIV reservoir size to biological aging and non-AIDS comorbidities in people on suppressive antiretroviral therapy, independent of inflammation and immune history.

The paper introduces the Digital PCR Data Essentials Standard (DDES) to standardize data structure for dPCR, improving interoperability and reproducibility across platforms and applications.

The paper identifies lncRNAs that coordinately regulate both transcription and post-transcriptional processing of their targets, showing tight coupling between lncRNA and target abundance, with implications for cancer gene regulation.

The paper develops a multiplexed digital PCR assay to quantify total and intact HIV-1 reservoirs, showing it is more specific than existing methods and enables high-throughput analysis.

This paper introduces three new statistical methods for variance estimation in digital PCR experiments, showing they provide more accurate results than classical binomial methods.

This paper introduces a 3'-end capture sequencing method for targeted gene expression profiling, achieving 100-fold enrichment of target genes with shallow sequencing.

The paper evaluates SILVER-Seq data for DNA contamination and finds low exonic and splice read fractions, suggesting contamination issues in the technology.