Cancer BiologyCancer Research CommunicationsPeer-reviewed
Small extracellular vesicles promote stiffness-mediated metastasis
Alexandra Sneider, Ying Liu, Bartholomew Starich…·Denis Wirtz
The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.