Robert A. Sweet

This study investigates how a genetic mutation affecting cytoskeletal structure in mice impacts mismatch negativity, a biomarker of sensory integration, and links structural and functional deficits in supragranular neocortex.

This study identifies a shared proteomic profile in Alzheimer's disease with and without psychosis and a separate molecular signature linked to postsynaptic density disruption.

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

The paper examines rare missense and loss of function variants in GWAS loci for Alzheimer's disease across families, finding that many families lack identifiable variants beyond APOE-e4.

This study examines CB1R levels in excitatory and inhibitory boutons in schizophrenia patients, finding increased CB1R in excitatory boutons and decreased in inhibitory ones, suggesting altered neurotransmission balance.

This study shows that overexpressing CACNB4 reduces small dendritic spine density in female mice but not males, linked to sex differences in the {beta}4 interactome.

This paper shows a Kalirin mutation enhances RhoA signaling, causing dendritic regression in mice during adolescence, linking it to schizophrenia-like structural impairments.

This study identifies MAP2 phosphorylation changes in schizophrenia, linking them to neuronal structure and synaptic function impairments through phosphoproteomics and transgenic mouse models.

This study identifies synaptic proteome alterations in the primary auditory cortex of schizophrenia patients, showing coordinated changes in postsynaptic proteins not explained by global protein levels or confounding factors.