Alexa L. Mattheyses

This paper identifies a reversible conformational change in the desmoplakin hinge domain in response to mechanical force, showing its role in mechanotransduction within desmosomes.

The paper shows N-cadherin is orientationally ordered at low mechanical load cardiomyocyte junctions but disordered at high load, indicating adaptation to local force conditions.

This study shows fluid shear stress increases clathrin-mediated endocytosis in endothelial cells at low stress but not high stress.

This study uses super-resolution imaging to show that mechanical stretch increases the distance between desmoplakin cytoplasmic tails in desmosomes, indicating a conformational shift in response to stress.

This study identifies RHOV as a detachment-sensitive Rho GTPase critical for ovarian cancer peritoneal metastasis by enhancing anoikis resistance and cytoskeletal remodeling.

The paper identifies the DSG2 interactome in neonatal cardiomyocytes, revealing shared and unique proteins involved in intercalated disc function.

This study investigates how actin dynamics influence clathrin-mediated endocytosis by altering vesicle formation routes and stability.

The paper investigates the architectural arrangement of desmoplakin isoforms in desmosomes using dSTORM and shows that tail domain position correlates with rod length.

OOPS is a MATLAB-based software for analyzing fluorescence polarization microscopy images, enabling efficient processing, structure detection, and visualization of polarization data.

This study shows fluidic shear stress increases clathrin dynamics and clathrin-coated vesicle formation in endothelial cells compared to static conditions.