Zachary T. Schafer

This study identifies TRAIL as a synthetic essentiality in VHL-deficient ccRCC, showing its regulation by HIF2 and its role in cell proliferation through the p38 MAPK pathway, suggesting a combination therapy strategy.

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

The paper investigates how ancestry-linked stromal variations, specifically PZP cells, influence breast epithelial cell invasion in African and European ancestry individuals.

The paper shows that developmental microglia in zebrafish die after becoming phagocytic, leading to a cycle of debris production and cannibalism that shortens their lifespan.

This study shows that Acod1 in cancer cells promotes immune evasion by releasing inhibitory peptides, not ITA, and that reducing Acod1 can make tumors responsive to PD-1 therapy.