Author

Loan Duong

University of Notre DameORCID 0000-0003-4785-7194Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Xin LüiD· 3 shared Guoqiang LiuiD· 2 shared Sharif RahmyiD· 2 shared Zachary T. SchaferiD· 2 shared Abigail E. EllisiD· 1 shared Adrian ChaoiD· 1 shared Ariana ArceiD· 1 shared Emma Albano· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

Xin LüORCID

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3 papers

Recent·Most cited

Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 1, 2026

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma

Xuechun Wang, Yujing Qin, Loan Duong…·Éva Szegezdi

This study identifies TRAIL as a synthetic essentiality in VHL-deficient ccRCC, showing its regulation by HIF2 and its role in cell proliferation through the p38 MAPK pathway, suggesting a combination therapy strategy.

DOI 10.1073/pnas.2535452123

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintNov 18, 2025

CDH3 as a Novel Therapeutic Target in Basal-like Double-Negative Prostate Cancer

Guoqiang Liu, Shiyu Wang, Loan Duong…·Xin Lü

This study identifies CDH3 as a key driver of basal-like prostate cancer and shows that CDH3-targeted therapies like ADCs and CAR T cells are effective in preclinical models.

DOI 10.1101/2025.11.18.689150

mousebulk RNA-seq

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Cancer BiologyCell ReportsPeer-reviewedMar 24, 2024

Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides

James H. Schofield, Joseph Longo, Ryan D. Sheldon…·Zachary T. Schafer

This study shows that Acod1 in cancer cells promotes immune evasion by releasing inhibitory peptides, not ITA, and that reducing Acod1 can make tumors responsive to PD-1 therapy.

18 citations

humanproteomics

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