Xuan Yao

This study compares how natural infection versus vaccination primes human CD4+ T cells, showing differences in TCR diversity, effector function, and integrin expression years later.

HDOCK-Multimer improves prediction of large protein complexes by combining docking and combinatorial assembly, outperforming existing methods on benchmark datasets.

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.