Guihai Liu

This study compares how natural infection versus vaccination primes human CD4+ T cells, showing differences in TCR diversity, effector function, and integrin expression years later.

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.