Boris Tichý

This study shows that paclitaxel resistance in triple-negative breast cancer is linked to DNA methylation changes, which can be partially reversed by decitabine to enhance chemosensitivity.

This study identifies TRβ as a driver of prostate cancer growth and shows that NH-3 inhibits PCa cell proliferation and tumor growth, particularly in castration-resistant models.

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

This study shows JUN suppresses prostate cancer progression by inducing senescence and immune cell recruitment, with JUN depletion accelerating tumor growth.

This paper introduces a method to estimate biological age using cell lineage trees derived from somatic mutations in scRNA-seq data, showing strong correlation with chronological age.

GLASS standardizes variant assessment from Sanger sequencing data, providing consistent output aligned with HGVS nomenclature.