A STAT5B-driven mouse model of hepatosplenic γδ T-cell lymphoma reveals therapeutic efficacy of JAK inhibition
Myint Myat Khine Aung, Susann Schönefeldt, Sophie Pfalz-Kraupp…·Heidi Anne Neubauer
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University of Veterinary Medicine ViennaORCID 0000-0001-7372-7786Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Myint Myat Khine Aung, Susann Schönefeldt, Sophie Pfalz-Kraupp…·Heidi Anne Neubauer
Aleksandra Fesiuk, Daniel Pölöske, Elvin D. de Araujo…·Lukas Kenner
This study identifies TRβ as a driver of prostate cancer growth and shows that NH-3 inhibits PCa cell proliferation and tumor growth, particularly in castration-resistant models.
Daniel Pölöske, Helena Sorger, Anna Schönbichler…·Richard Moriggl
This study evaluates small molecule STAT3/5 inhibitors for treating AML and NKCL, showing growth arrest and synergy with existing therapies in vitro and in vivo.
Christina Sternberg, Martin Raigel, Tanja Limberger…·Lukas Kenner
This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.
Torben Redmer, Martin Raigel, Christina Sternberg…·Lukas Kenner
This study shows JUN suppresses prostate cancer progression by inducing senescence and immune cell recruitment, with JUN depletion accelerating tumor growth.