Ye Zhan

The paper investigates how enhancer-driven 3D chromatin domain folding regulates transcription in human mammary tumor cells following estradiol stimulation.

This study shows Prmt5 regulates gene expression and chromatin organization during adipogenesis by modulating TAD boundaries and chromatin loop anchors.

The paper generates chromosome-level reference genomes for two C. briggsae strains, improving genomic resources for comparative genomics in the Caenorhabditis genus.

The paper presents a chromosome-level genome assembly of the Atlantic silverside and reports high heterozygosity and extensive structural variation linked to local adaptation.

The paper assembles the genome of Symbiodinium microadriaticum using Hi-C and describes its unique chromosomal structure and organization.

The paper evaluates reproducibility and quality measures for Hi-C data using real and simulated datasets, showing that specialized methods outperform simple correlation analysis.

This study shows that SmcHD1 prevents TAD formation on the inactive X chromosome by altering chromatin structure and epigenetic marks.

This paper presents an integrative framework to detect structural variants in cancer genomes using multiple methods and finds that non-coding structural variation significantly impacts genome function in cancer cells.

The paper investigates the HoxD cluster's role as a dynamic TAD boundary in limb development, showing its resilience and ability to maintain regulatory segregation.