Maryamsadat Seyedsadr

This study identifies age-associated senescent CD4+ T cells as drivers of autoimmunity in CIDP, showing that senolytic and senomorphic therapies can mitigate disease.

This study develops a CD8 T cell-dependent model of MS and identifies differences in brain and spinal cord inflammation, showing that IFN-g and PD-1 signaling regulate CD8 T cell-mediated neuroinflammation.

This study identifies UTX's role in regulating progenitor CD8+ T cell fate in T1D by interacting with TCF1 and STAT3, showing its importance in autoimmune diabetes progression.

This study identifies impaired type I IFN and IL-27 signaling in RRMS Tregs and shows that cGAMP-MPs restore Treg suppressive function in EAE.

The paper identifies IL-21-expressing CD4+ T cells in an inflammatory neuropathy mouse model and shows their role in neuropathy development through clonal expansion and CXCR6-mediated infiltration.