Author

Zsu‐Zsu Chen

Beth Israel Deaconess Medical CenterORCID 0000-0001-9441-675XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Robert Edgardo GerszteniD· 4 shared Usman A. TahiriD· 3 shared Alexis C. WoodiD· 2 shared Clary B. ClishiD· 2 shared Gaurav TiwariiD· 2 shared Jerome I. RotteriD· 2 shared Kent D. TayloriD· 2 shared Laurie A FarrelliD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersPhysiology

Robert Edgardo GersztenORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintAug 7, 2026

Genetic drivers of protein changes over time: Findings, considerations, and approaches in TOPMed cohorts and UK Biobank

Madeline G Gillman, Han Chen, Annie Green Howard…·Laura M. Raffield

The paper identifies genetic drivers of protein change over time using longitudinal proteomics data from MESA, UK Biobank, and CARDIA, finding that baseline adjustment improves replication but may introduce biases.

DOI 10.64898/2026.08.03.742409

humanproteomics

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PhysiologybioRxivPreprintJun 30, 2025

Acute cold exposure in humans shifts the circulating proteome to a cardioprotective and anti-aging profile

Kaja Plucińska, Zsu‐Zsu Chen, Ruijie Xiang…·Paul Cohen

This study identifies a proteomic signature in humans following acute cold exposure that correlates with cardioprotective and anti-aging effects.

2 citations

humanproteomics

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Genetic & Genomic MedicineHuman Genetics and Genomics AdvancesPeer-reviewedMay 7, 2024

A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically-determined protein-protein networks

Yi-Ting Tsai, Yana Hrytsenko, Michael Elgart…·Tamar Sofer

The paper introduces a parametric bootstrap method to compute confidence intervals for genetic correlations, applied to protein-protein networks from proteomics data.

1 citation

humanproteomics

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PhysiologyNature MetabolismPeer-reviewedMar 18, 2024

Lac-Phe mediates the anti-obesity effect of metformin

Shuke Xiao, Veronica L. Li, Xuchao Lyu…·Jonathan Z. Long

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

86 citationstop 1%

mousehuman

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