Xuchao Lyu

This study identifies MCT6 as an intestinal exporter of Lac-Phe, showing its role in metformin-induced weight loss and systemic metabolite regulation.

This study identifies a PTER inhibitor that reduces food intake and body weight in mice, linking PTER function to obesity treatment.

This study identifies a secondary BHB metabolic pathway mediated by CNDP2, leading to BHB-amino acid metabolites that regulate energy balance in mice and humans.

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

The paper identifies ENPP3 as a second cGAMP hydrolase, showing it regulates cGAMP levels and impacts cancer immunity.

This study maps the organism-wide secretome response to exercise in mice, identifying 200+ exercise-regulated protein pairs and uncovering anti-obesity and anti-diabetic roles of a liver-secreted proteoform.