Jacob M. Allen

This study shows social stress worsens colitis via beta-adrenergic and NADPH oxidase-driven oxidative stress, with beta-blockers and apocynin reducing inflammation.

This paper uses meta-analysis and machine learning to show plant-protein diets increase gut microbial diversity and specific taxa, while animal-protein diets favor proteolytic taxa and different metabolic pathways.

This study optimizes a PROTAC to degrade IDO1 with high potency in GBM cells, showing sustained degradation via the ubiquitin-proteasome system.

This study investigates how influenza A virus infection during pregnancy affects maternal intestinal immunity and fetal brain development, finding dose-dependent effects without increased IL-17 signaling.

This study identifies aryl-lactates as bioactive metabolites in fermented foods and shows their production can be enhanced to boost AhR receptor activity.

This study shows that aging alters gut microbiota immunogenicity, increasing TLR4 activation and inflammation, and that these changes are linked to heightened host inflammation.