Polina Prokofeva

This paper introduces a method using high-intensity longwave UV light to rapidly perform in-cell photo-crosslinking with minimal photodamage, enabling fast analysis of biomolecular interactions.

The paper identifies inhibitor-induced kinase destabilization as a common phenomenon and reveals that it occurs through endogenous proteolytic mechanisms rather than classical ubiquitination.

This paper introduces Prosit-PTM, a deep learning model for PTM discovery that improves zero-shot prediction using a synthetic dataset and chemically-informed encoding.

The paper evaluates proteome analysis performance across different chromatographic flow rates and shows that all are suitable for high-quality analysis, with capLC being a robust alternative to nanoLC.

A single small molecule degrader targets 13 out of 17 prevalent oncogenic KRAS alleles, inhibiting growth of KRAS-driven cancer cell lines and inducing tumour regression in vivo.