Gerhard Wiche

This study shows that multicellular systems coordinate force generation and invasive migration through oscillatory mechanochemical feedback in 3D matrices.

The paper shows that keratin bundling in epithelial cells under stretch allows the nucleus to escape its keratin cage, providing a mechanism for tissue adaptation to mechanical stress.

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

This study shows that plectin increases fibroblast stiffness and protects against actin network disruption under compression.

This study identifies impaired autophagic flux in skeletal muscle of EBS-MD patients and plectin-deficient models, linking it to protein aggregation pathology.

This study identifies plectin as a critical mediator of mechanical homeostasis in hepatocellular carcinoma, showing that its inhibition suppresses tumor growth and metastasis.

The paper engineers a recombinant actin-vimentin crosslinker, ACTIF, which forms composite bundles and stiffens actin-vimentin networks, demonstrating modularity in crosslinker design.

This study shows that plectin is essential for intestinal epithelial integrity and protects against colitis by maintaining mechanical stability and junctional function.