Annabelle Thibessard

SYNTERUPTOR identifies genomic islands containing specialised metabolite gene clusters in microbial genomes, detecting clusters missed by existing tools.

This study shows that NucS, a mismatch repair endonuclease in Streptomyces, reduces mutation rates by correcting G/T mismatches and influences the mutational spectrum along the chromosome.

The paper shows that ribosomal RNA operons in Streptomyces define a central functional compartment in the chromosome, with dense core genes and high expression levels.