Jean‐Luc Pernodet

This study relocates a gene cluster to the central chromosomal compartment in Streptomyces, enhancing its transcription and antibiotic production without altering chromosome compaction.

SYNTERUPTOR identifies genomic islands containing specialised metabolite gene clusters in microbial genomes, detecting clusters missed by existing tools.

This study identifies galbonolides as metabolites produced by Streptomyces AgN23 that modulate plant immunity and promote rhizosphere colonization by triggering defense mechanisms and inhibiting competitors.

The paper shows that ribosomal RNA operons in Streptomyces define a central functional compartment in the chromosome, with dense core genes and high expression levels.

The paper develops a marker-free genome engineering method for Amycolatopsis using the pSAM2 site-specific recombination system to efficiently delete genes or large DNA regions.