Pierre Leblond

The paper shows conjugation in Streptomyces leads to large-scale chromosomal transfer, causing genetic diversification of antibiotic gene clusters.

SYNTERUPTOR identifies genomic islands containing specialised metabolite gene clusters in microbial genomes, detecting clusters missed by existing tools.

This study shows that NucS, a mismatch repair endonuclease in Streptomyces, reduces mutation rates by correcting G/T mismatches and influences the mutational spectrum along the chromosome.

The paper shows that ribosomal RNA operons in Streptomyces define a central functional compartment in the chromosome, with dense core genes and high expression levels.