Emilio Cirri

This study compares proteolytic pathway activity in neuronal compartments across aging in mice and C. elegans, revealing age-related differences in UPS and macroautophagy.

This study investigates sex-dependent proteomic changes in young and aged mouse peripheral nerves during ex vivo degeneration, revealing sex-specific molecular features of nerve ageing.

Across three German sites and 207 analyzed mice, systemic rhNRGβ1 at 10 µg/kg did not reduce schwannoma nerve thickness or shift Schwann cell differentiation markers.

This study identifies acetylation-dependent remodeling of the secretory pathway in senescence, showing its role in shaping the senescence-associated secretome.

This paper identifies transient GSK3β activation as a mechanism promoting disease tolerance to sepsis through hypometabolism, without affecting pathogen burden.

This paper uses multi-omic profiling in a mouse stroke model to show that host and microbial changes converge around day 7 post-injury.

This study identifies chronic stress as a systemic molecular state across tissues in mice, showing that NPBWR1 inhibition reverses stress-related changes in multiple organs and sexes.

This study shows that chronic stress accelerates brain aging in young mice but activates age-specific anti-aging programs in old mice.

This study compares molecular changes in PNS ageing, dietary restriction, and injury, finding similar proteomic signatures between ageing and injury.

This study shows YIPF5 regulates ER export of specific proteins, and its disruption causes neuronal migration defects and microcephaly.

This study identifies polyamines as key regulators of epithelial regeneration in aged intestines, showing they enhance protein homeostasis and restore regenerative capacity through dietary manipulation.

This study identifies CCB79 as a primate-specific protein essential for maintaining neural progenitor diversity in developing brains by regulating ciliogenesis.

This study shows that amyloid-beta precursor protein contributes to non-pathological brain aging and learning decline in killifish and humans.

The paper introduces an automated workflow for BioID to improve reproducibility and identification of protein-protein interactions by increasing throughput and reducing sample input requirements.

The paper shows that IER3IP1 mutations cause microcephaly by blocking ER-Golgi transport, leading to neuronal migration defects and ER distension.

The paper investigates how LPS preconditioning affects microglial proteome response to focal ischemic brain injury in mice, finding significant neuroprotection and changes in proteome patterns linked to type I interferons.

This study investigates changes in the myelin proteome of mouse peripheral nerves during aging, finding only subtle changes and proposing the dataset as a resource for future research.

The paper identifies RFX7 target genes through multi-omics analysis, revealing their role in tumor suppression and neuronal processes.

The paper reports the genome of Seminavis robusta, a benthic diatom, revealing gene family expansions and adaptations related to light and oxygen sensing, and provides insights into genetic diversity and gene function in benthic diatoms.