Christoph Kaether

This study identifies acetylation-dependent remodeling of the secretory pathway in senescence, showing its role in shaping the senescence-associated secretome.

This study examines how aging and Klotho deletion affect choroid plexus structure and function, finding that Klotho deficiency increases age-related calcification in specific regions.

This study shows YIPF5 regulates ER export of specific proteins, and its disruption causes neuronal migration defects and microcephaly.

The paper creates a cell-type-specific lysosome protein atlas in the brain, identifies SLC45A1 as a neuron-specific lysosomal protein, and shows its role in lysosomal function and neurodegeneration.

NanTex enables multiplexing and phenotyping of organelles using nanotexture descriptors from single-channel super-resolution microscopy data across multiple modalities.

The paper shows that IER3IP1 mutations cause microcephaly by blocking ER-Golgi transport, leading to neuronal migration defects and ER distension.

The paper identifies YIPF5 and GOT1A/B as components of ER export and shows ATF6 has a transcription-independent role in ER export inhibition by FLI-06.

The paper identifies conserved paralog substitutions during neuronal differentiation across species and shows their impact on neuron development.