Author

Hao-Hsuan Hsieh

QB3ORCID 0000-0001-9629-5832Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:yeast· 3 Assay:cryo-EM· 1 Assay:proteomics· 1

Frequent Co-Authors

Andreas MartiniD· 3 shared Ayush SaurabhiD· 1 shared Christine L. GeeiD· 1 shared Connor ArkinsoniD· 1 shared Diego R Ramos-Ortiz· 1 shared Erika M. López-Alfonzo· 1 shared Ken C. DongiD· 1 shared Sahar Zarafshan· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

Andreas MartinORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 20, 2026

Molecular basis of ubiquitin-independent recognition and degradation of ODC/Antizyme by the 26S proteasome

Diego R Ramos-Ortiz, Hao-Hsuan Hsieh, Ken C. Dong, Andreas Martin

This study identifies the mechanism by which antizyme mediates ubiquitin-independent degradation of yODC by the 26S proteasome through structural and biochemical analysis.

DOI 10.64898/2026.07.19.739413

yeastexperimental assay

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BiochemistrybioRxivPreprintJun 2, 2026

Chaperones shape the conformational landscape of 26S-proteasome-base assembly for allosteric ATPase motor activation

Hao-Hsuan Hsieh, Andreas Martin

This study reveals how chaperones guide the conformational transitions of the 26S proteasome base subcomplex through intermediates to achieve ATPase activity.

1 citation

yeastcryo-EM

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BiochemistryNature CommunicationsPeer-reviewedMar 24, 2026

Substrate-interacting pore loops of two ATPase subunits determine the degradation efficiency of the 26S proteasome

Erika M. López-Alfonzo, Ayush Saurabh, Sahar Zarafshan…·Andreas Martin

This study investigates how pore-1 loops of ATPase subunits in the 26S proteasome affect substrate degradation efficiency using biochemical and single-molecule assays with yeast proteasomes.

8 citationstop 3%

yeastproteomics

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