Michael P. Vincent

This study improves LC-MS metabolomics by reducing background ion burden from tributylamine, enhancing signal intensity and feature coverage across multiple biological samples.

This study shows that loss of PROX1 in adult mouse Schlemm's canal leads to permanent ocular hypertension by converting the canal to a vein-like phenotype.

This study shows dietary restriction enhances CD8+ T cell ketolysis, improving mitochondrial function and anti-tumor immunity by reducing exhaustion.

This study identifies glucose-dependent glycosphingolipid biosynthesis as essential for CD8+ T cell expansion and tumor control, independent of energy production.

The paper shows that metabolite extracts contain active enzymes and demonstrates a new workflow to remove proteins for improved metabolomics.

This study identifies an intrinsically disordered protein region in CLEC16A critical for mitochondrial quality control and diabetes prevention.

Disorder Atlas provides a web-based tool for interpreting intrinsic disorder predictions using proteome-based statistics and enables large-scale exploration of disorder features.