Human Rezaei

This study investigates the early unfolding events of the E200K mutant prion protein in bank voles, comparing it to the wild-type protein to understand its enhanced capacity to generate PrPSc.

This study shows non-fibrillar prion protein oligomers can transmit folding information during early assembly, challenging the classical fibril-end templating model.

The paper investigates the early steps of PrPC unfolding during PrPSc propagation using NMR and simulations, identifying key regions and mechanisms of unfolding/refolding.

This paper introduces PrP E219K as a new substrate for RT-QuIC that amplifies multiple human prion strains and enables discrimination between sporadic and variant CJD strains.

This paper develops a stochastic reaction-diffusion model to study prion spreading dynamics, showing how non-linear tissue responses and replication kinetics interact to explain strain-specific phenotypes and neuro-invasion.

The paper compares two prion growth models, showing that the detailed balance between PrPSc and suPrP can replace the induced-fragmentation model.

The paper shows that structurally diverse PrPSc assemblies complement each other to cross species barriers, supporting the quasi-species concept in prions.

This study investigates the structural convergence and diversification of PrPSc assemblies during prion replication, revealing a secondary templating pathway that explains structural diversification.