Ian Seim

This study investigates how ionic strength and membrane adsorption influence septin polymerization, showing salt-dependent cooperativity and context-dependent assembly modes.

The paper shows that mRNA interactions promote cotranslational association of heteromeric hERG1a/1b ion channels, with structural diversity and mRNA interactions influencing translation modes.

The paper shows RNA promotes synapsin phase separation, forming condensates that organize synaptic vesicles and enhance local translation.

The paper develops a genetic algorithm to study how synonymous mutations affect mRNA structure and reveals a physical code in the genetic code that influences RNA-protein complex properties.

The paper shows that temperature affects the material properties of Whi3 condensates in fungi, which are optimized by sequence changes for specific climates.

This study shows that SARS-CoV-2 N-protein uses two distinct RNA motifs, both requiring dsRNA, to drive phase separation at specific temperatures, enabling multiple viral functions.