Amy S. Gladfelter

The paper models nuclear division in a branching fungal network to show that asynchronous cycles and density-responsive branching stabilize nuclear density.

This study uses molecular dynamics simulations to show how amphipathic helix domains cooperate in binding to lipid membranes, stabilizing septin structures.

The paper investigates nuclear selection in chimeric fungi during different life stages, finding strong selection during spore germination and mycelium establishment but not during mycelium growth.

The paper investigates how RNA-protein binding site context, not just valence, affects biomolecular condensate properties in Ashbya gossypii.

The paper shows that Whi3 condensates regulate local translation in syncytial fungi, linking condensate composition and RNA features to spatially patterned translation during cell growth.

This study shows that lipid packing and membrane geometry jointly regulate septin localization in vitro and in cells.

This study examines mitotic nuclear segregation in the multibudding yeast Aureobasidium pullulans, revealing distinct mechanisms compared to uninucleate yeasts.

This study investigates how ionic strength and membrane adsorption influence septin polymerization, showing salt-dependent cooperativity and context-dependent assembly modes.

The paper shows that core and shell proteins in paraspeckles compete for RNA binding, leading to layered condensate organization through immiscibility and competitive binding.

The paper shows that mRNA interactions promote cotranslational association of heteromeric hERG1a/1b ion channels, with structural diversity and mRNA interactions influencing translation modes.

The paper designs and tests 25 optimized vectors for genetic engineering of Aureobasidium pullulans, enabling dual protein expression and homology-based gene modification.

This study investigates how charge distribution and helical content of amphipathic helix domains affect septin binding to lipid membranes using simulations and experiments.

The paper shows RNA promotes synapsin phase separation, forming condensates that organize synaptic vesicles and enhance local translation.

The paper identifies Pak1 as a key protein mediating negative feedback in yeast to enable multiple polarity sites and budding.

The paper investigates how RNA-RNA interactions in viral replication are controlled by biomolecular condensates, showing that sequence complementarity and condensate properties influence RNA organization.

The paper develops a genetic algorithm to study how synonymous mutations affect mRNA structure and reveals a physical code in the genetic code that influences RNA-protein complex properties.

The paper biochemically characterizes KpAspE, a Group 5 septin from Knufia petricola, showing it recapitulates functions of canonical septin hetero-octamers in vitro.

The paper shows that temperature affects the material properties of Whi3 condensates in fungi, which are optimized by sequence changes for specific climates.

This study compares syncytiotrophoblast gene expression in placental tissue and trophoblast organoids using snRNA-seq, identifying distinct nuclear subtypes and environmental influences on STB gene expression.

This study shows that SARS-CoV-2 N-protein uses two distinct RNA motifs, both requiring dsRNA, to drive phase separation at specific temperatures, enabling multiple viral functions.

The paper shows that guanidine hydrochloride reactivates an ancient septin hexamer assembly pathway in yeast by mimicking a missing arginine sidechain in Cdc3.