Author

Joseph J. Maciag

Cincinnati Children's Hospital Medical CenterORCID 0000-0001-9741-5082Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexander R. HorswilliD· 1 shared Andrew B. HerriD· 1 shared Bryce Guion· 1 shared Can Wang· 1 shared Carl BlobeliD· 1 shared Conner E. Slone· 1 shared D. Ashley RobinsoniD· 1 shared Hala F. Alnajjar· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMicrobiology

Alexander R. HorswillORCID

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2 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedJun 13, 2025

Structural Insights into the Activation and Inhibition of the ADAM17-iRhom2 Complex

Joseph J. Maciag, Conner E. Slone, Hala F. Alnajjar…·Tom C. M. Seegar

The paper presents the cryo-EM structure of the ADAM17-iRhom2 complex, elucidates its inhibitory mechanisms, and validates findings with cellular assays.

8 citations

cryo-EMexperimental assay

𝕏 PostBluesky

MicrobiologyCell ReportsPeer-reviewedApr 1, 2024

Staphylococcus aureus skin colonization is mediated by SasG lectin variation

Krista B. Mills, Joseph J. Maciag, Can Wang…·Alexander R. Horswill

This study identifies SasG-II, a variant of the S. aureus surface protein, which binds to a broader range of ligands, enhancing its ability to colonize skin.

25 citationstop 2%

experimental assayhost-pathogen & immune response

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