Alexander R. Horswill

This paper identifies a teichoic acid-like cell wall modification in Streptococcus pyogenes that mediates immune suppression and is regulated by quorum sensing.

This study shows that collagen binding adhesin (Cna) in Staphylococcus aureus reduces skin infection severity by binding to C1q and limiting inflammation.

The paper identifies glycolipids and lipoteichoic acid alanylation as factors contributing to Group B streptococcal diabetic wound infection using a transposon mutant screen in a murine model.

This study shows that Eap proteins in S. aureus biofilms reduce porosity and prevent macrophage invasion, enhancing biofilm survival during prosthetic joint infections.

This study shows that Pseudomonas aeruginosa proteases cleave SasG in Staphylococcus aureus to induce aggregation and biofilm formation in chronic wound co-infections.

This study shows that androgens like testosterone promote S. aureus pathogenesis by activating the agr quorum sensing system, leading to increased virulence and skin infection.

This study shows that Nuc1 in MRSA regulates biofilm formation, dispersal, and the size of detached cell aggregates by degrading extracellular DNA.

This study identifies SasG-II, a variant of the S. aureus surface protein, which binds to a broader range of ligands, enhancing its ability to colonize skin.

This study develops a cost-effective media to mimic the human skin environment and shows it enhances the expression of virulence factors in MRSA.

This study shows X-rays can drive hydride transfer in bacterial DHFRs, revealing conformational changes and catalytic dynamics through high-resolution crystal structures.