Carlos Lopez-Garcia

The paper compares organotypic cultures and xenografts of a human lung squamous cell carcinoma model, finding that xenografts better reflect tumor gene expression and reveal NOTCH1 loss as a driver.

The paper develops an in vitro model of lung squamous cell carcinoma using primary human bronchial epithelial cells to study genotype-phenotype relationships in cancer progression.

The paper introduces XTABLE, an open-source tool for analyzing PML transcriptomic data, and uses it to study chromosomal instability as a biomarker for LUSC progression and pathway onset.