Caroline Dive

This paper introduces a 3D imaging pipeline to detect functionally perfused vasculogenic mimicry in mouse tumor models, providing evidence of its presence and functionality.

The paper compares organotypic cultures and xenografts of a human lung squamous cell carcinoma model, finding that xenografts better reflect tumor gene expression and reveal NOTCH1 loss as a driver.

This study shows glucocorticoids enhance anti-tumor immunity by inhibiting the GARP/TGF-β axis in melanoma, improving prognosis and response to immunotherapy.

This study shows circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations, which activate endothelial and immune cells and contribute to pre-metastatic niche formation.

The paper identifies ATOH1 as a pro-metastatic oncogenic driver in SCLC by showing its role in cell survival and metastasis suppression upon depletion.

The paper develops an in vitro model of lung squamous cell carcinoma using primary human bronchial epithelial cells to study genotype-phenotype relationships in cancer progression.

The paper introduces XTABLE, an open-source tool for analyzing PML transcriptomic data, and uses it to study chromosomal instability as a biomarker for LUSC progression and pathway onset.