Juan Luis Mateo

The paper develops a base editing framework in medaka and zebrafish to functionally validate SNVs, demonstrating its application in recreating cardiac phenotypes and validating candidate genes for congenital heart disease.

This study shows that BMP signaling disrupts optic chiasm formation and retinal ganglion cell (RGC) pathfinding in zebrafish by affecting midline guidance cues and optic stalk morphogenesis.

This study identifies TGF{beta} as essential for optic fissure fusion, with BMP antagonists preventing excessive BMP signaling to facilitate closure.