Alper Küçükural

The paper shows HIV uses Vpr to increase TRAIL-R2 expression in CD4+ T cells, which enhances NK cell killing through non-canonical TRAIL signaling.

The paper shows that tRNA-derived RNAs (tDRs) in sperm of C. elegans can transmit epigenetic phenotypes to offspring through RNaseT2-mediated regulation of tDR length.

The paper introduces Worm Perturb-Seq (WPS) to perform high-resolution RNA-seq on perturbed C. elegans, identifying gene regulatory networks and showing pairwise modularity in nuclear hormone receptor regulation.

This study shows that Sod1G85R knock-in mice exhibit up-regulated cholesterol synthesis pathways and limited neurodegeneration, contrasting with severe TgSOD1G93A mice, suggesting lipid pathway dysregulation in ALS.

The paper creates a single-cell atlas of the murine epididymis and vas deferens, identifying cell types and their regional specialization, and revealing potential signaling networks.

DolphinNext provides a graphical interface for creating, deploying, and executing Nextflow pipelines to improve reproducibility and portability in genomic data analysis.

The paper identifies four human adipocyte subtypes through single-cell transcriptomics and describes their developmental mechanisms and functional roles.

DEBrowser provides an interactive tool for differential expression analysis of count data without programming skills, demonstrating its capabilities on published datasets.