Xiaoyang Zhang

This study investigates the differential roles of HNF4α isoforms P1 and P2 in PDAC growth and differentiation, finding P2 supports growth better than P1.

This study shows FoxA1/2 reprogram the epigenome of NKX2-1-negative lung adenocarcinoma to drive a gastric lineage switch through DNA demethylation and regulatory element activation.

The paper introduces HAPI, a 3D genomics method, to identify enhancer hijacking in cancer cell lines, revealing novel oncogene activation mechanisms.

The paper identifies estrogen-induced chromatin looping changes in endometrial cancer cells and shows their correlation with transcriptional responses, though not all loops are essential for estrogen regulation.

This paper shows SS18::SSX fusion protein alters BAF chromatin remodeler distribution, leading to transcriptional activation and repression by changing histone modifications at regulatory regions.

This study identifies cis-regulatory elements that control transcriptional timing and noise in response to estrogen using single-cell RNA-seq and machine learning.

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.