Masayo Koide

This study shows that Arf6 maintains PIP2 levels in capillary endothelial cells, sustaining Kir2.1 channel activity and functional hyperemia, and identifies Arf6 as a therapeutic target for cerebral blood flow restoration.

This study shows that endothelial EGFR signaling is crucial for functional hyperemia, as its deletion impairs cerebral blood flow responses to neuronal activity.

This study shows that pathogenic tau peptides reduce endothelial calcium signaling and vasodilation in brain microvessels, impairing cerebral blood flow.

The paper demonstrates that brain capillary endothelial cells and pericytes express functional KATP channels that regulate membrane potential and cerebral blood flow through adenosine signaling.