Eric E. O’Neill

This study identifies a pre-rRNA positive feedback loop driven by CK2 in the nucleolus that promotes malignant ribosome biogenesis and cancer growth.

This paper reviews preclinical studies on PI3K-gamma inhibition to reverse myeloid-driven immune suppression in solid tumours, finding that combination therapies show greater antitumor effects than monotherapy.

The paper shows that ionizing radiation enhances immunotherapy in pancreatic cancer by increasing tissue-resident NK cells that support CD8 T cell activity through cDC1-dependent mechanisms.

The paper introduces a deep learning framework, CIGER, for predicting gene expression rankings induced by chemicals and applies it to pancreatic cancer drug repurposing, showing improved performance over existing methods.