Author
Peter the Great St. Petersburg Polytechnic UniversityORCID 0000-0002-0070-4898Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Bogdan Kirillov, Aleksandra Vasileva, O. Fedorov…·Konstantin Severinov
This paper introduces an active learning method to discover PAMs for uncharacterized CRISPR-Cas9 orthologs without sequencing, reducing data requirements and validating it on known and novel Cas9 variants.
Aleksandr Andreevich Alekseev, Mikhail M. Kutuzov, Ekaterina A. Belousova…·O. I. Lavrik
The paper shows PARP1 binding weakens nucleosome core contacts using optical tweezers.
Aleksandra Vasileva, Marina Abramova, Polina Selkova…·Konstantin Severinov
This study characterizes SuCas9, a compact Cas9 ortholog from Streptococcus uberis, showing it can cleave DNA in vitro and function in human cells with a novel PAM sequence.
Aleksandr Andreevich Alekseev, Valerii Klimko, Marina Abramova…·Anatolii Arseniev
The paper describes modifications to the CRISPR-Cas12d system, identifies catalytically inactive variants, and demonstrates their high specificity using single-molecule techniques.