BiophysicsNucleic Acids ResearchPeer-reviewed
Single-molecule studies reveal the off-pathway elemental pause state as a target of streptolydigin inhibition of RNA polymerase and its dramatic enhancement by Gre factors
Anatolii Arseniev, Mikhail Panfilov, Georgii Pobegalov…·Mikhail A. Khodorkovskii
This study uses single-molecule techniques to show streptolydigin induces pauses in RNA polymerase, which are enhanced by Gre factors, revealing a new mechanism for antibiotic action.