Author

Xuan Xie

Michigan State UniversityORCID 0000-0002-0075-6612Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xuan Xie1 paper · Institute for Bioscience and Biotechnology Research

Biology Disciplines

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Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Ashley V. MakelaiD· 1 shared Ben LehneriD· 1 shared Chima V. MadukaiD· 1 shared Christopher H. ContagiD· 1 shared Evran E. UraliD· 1 shared Xia Sun· 1 shared Xianghua LiiD· 1 shared Yuheng WangiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 12 mutual co-author links

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1 shared paperImmunology

Ashley V. MakelaORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintApr 30, 2025

Persistent endotoxin exposure in macrophages elicits an immunometabolic profile susceptible to NF-kB and p53 perturbation

Chima V. Maduka, Xuan Xie, Ashley V. Makela…·Christopher H. Contag

This study shows that persistent LPS exposure in macrophages leads to a unique immunometabolic profile with altered oxygen consumption, ATP levels, and glycolysis, distinct from short-term LPS responses.

DOI 10.1101/2025.04.30.651567

mousebulk RNA-seq

𝕏 PostBluesky

GeneticsNature CommunicationsPeer-reviewedSep 9, 2023

Dominance vs. epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles

Xuan Xie, Xia Sun, Yuheng Wang…·Xianghua Li

The paper investigates how mutations interact in diploid organisms, showing that epistasis and dominance are common, context-dependent, and change with system complexity and conditions.

15 citations

𝕏 PostBluesky