Author

Madeline N. Hayes

University of TorontoORCID 0000-0002-0089-8995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alex Weiss· 3 shared Ivette Valencia-SamaiD· 2 shared Lynn KeeiD· 2 shared Meredith S. IrwiniD· 2 shared Adam ShlieniD· 1 shared Anisha Rajaselvam· 1 shared Anita VillaniiD· 1 shared Bret J. PearsoniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Alex Weiss

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 25, 2026

Efficacy of RMC-6236 (Daraxonrasib) and novel combination strategies targeting resistance in RAS pathway-driven neuroblastoma

Ivette Valencia-Sama, Lynn Kee, Alex Weiss…·Meredith S. Irwin

This study evaluates RMC-6236 and avutometinib in neuroblastoma models with RAS/MAPK pathway alterations, showing efficacy and identifying combination strategies to overcome resistance.

DOI 10.64898/2026.06.24.734371

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyCell ReportsPeer-reviewedApr 1, 2025

DNA Damage Response Deficiency Enhances Neuroblastoma Progression and Sensitivity to Combination PARP and ATR Inhibition

Madeline N. Hayes, Sarah Cohen‐Gogo, Lynn Kee…·Meredith S. Irwin

This study shows DDR gene mutations enhance neuroblastoma progression and sensitivity to PARP + ATR inhibitors in zebrafish models and human cells.

9 citations

zebrafishwhole-genome sequencing

𝕏 PostBluesky

Cancer BiologyeLifePeer-reviewedJan 10, 2024

A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCA H1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo

Alex Weiss, Cassandra D’Amata, Bret J. Pearson, Madeline N. Hayes

This study develops a zebrafish model of glioblastoma driven by specific oncogenic variants and shows inflammation inhibits tumor growth during initiation and relapse.

11 citations

zebrafishspatial transcriptomics

𝕏 PostBluesky